Red Grape Seed Extract (RGSE) declines Neuronal and Oxidative Damage in the Brain Regions of Alzheimer’s Induced Wistar Rats.

Asian Journal of Biological and Life Sciences,2023,12,3,551-557.
Published:February 2024
Type:Research Article
Author(s) affiliations:

M.Thulasi1, K. Janardhana2, C. Aruna3, M. Muniya Naik4, A. Govardhan Naik5, V. Uday Kiran

1Department of Zoology, SVA Government College for men, Srikalahasti, Tirupati, Andhra Pradesh, INDIA.

2Department of Zoology, Government Degree College, Rajampeta, Andhra Pradesh, INDIA.

3Department of Botany, Dr.YSR Government Degree College, Vedurukuppam, Chittoor, Andhra Pradesh, INDIA.

4Department of Zoology, Govt. Degree College, Rayachoty, Andhra Pradesh, INDIA.

5Department of Zoology, SVU College of Sciences, Sri Venkateswara University, Tirupati, Andhra Pradesh, INDIA.


Objectives: This research explores Red Grape Seed Extract (RGSE) declines Neuronal and Oxidative Damage in the brain regions of Alzheimer’s Induced Wistar Rats. Materials and Methods: A cohort of three-month-old Wistar rats were divided into two groups, receiving either a standard diet (control diet) or a diet supplemented with 2% RGSE over a 60-day period. RGSE, containing 592.5 mg/g dry weight of Total Phenolic Content (TPC), consisted of Gallic acid (49 mg/g), Catechin (41 mg/g), Epicatechin (66 mg/g), and Proanthocyanidins (436.6 mg catechin equivalents/g). Results: Longterm RGSE diet feeding proved well-tolerated, exhibiting no fatalities or behavioral abnormalities. Furthermore, no irregularities in food consumption or body weight were observed. The levels of Amyloid-beta (Aβ) in the brains of Wistar rats subjected to RGSE were notably lower compared to Alzheimer ‘s-induced Wistar rats on the control diet. Additionally, RGSE administration led to a reduction in amyloid plaques and microgliosis in the brains of Alzheimer’s-induced Wistar rats. Conclusion: The polyphenol component of RGSE demonstrated a substantial decrease in brain Aβ load and microglia activation. Ultimately, polyphenol-rich RGSE exhibited the potential to inhibit Aβ deposition and alleviate neuronal and oxidative damage in the Wistar rat model, suggesting its promise in delaying the progression of Alzheimer’s disease.