To investigate antioxidant and neuroprotective activity of ethanolic (OCWE) and acetone extract (OCWA) of Oldenlandia corymbosa plant and identification of phytochemical constituents present in both extracts by GC-MS analysis. The antioxidant potential of O. corymbosa was evaluated by DPPH and ABTS assays. MTT assay was used to test the plant’s neuroprotective effect on neuroblastoma cell lines. Phytoconstituents of said extracts have been quantified by GC-MS method. Ethanolic extract of plant showed lowest IC50 value (130.56μg/mL) compared to acetone extract (189.33μg/mL). More neuroprotective effect also exhibited by ethanolic extract. GC-MS analysis revealed the presence of numerous biologically active phytoconstituents in both extracts. On the basis of antioxidant and in-vitro neurotoxicity studies it is revealed that ethanolic extract of the plant showed more antioxidant and neuroprotective activity compared to the acetone extract and this may be due to the presence of antioxidant and anti-inflammatory fractions such as neophytadiene, squalene, stigmasterol and thunbergol.