Green Synthesis of AgNP Using Ficus benghalensis Aerial Root and its AchE Inhibiting Property

Aim: The aim of the study was to analyze the phytochemical components of adventitious roots of Ficus benghalensis and its biopotential ability on silver nanoparticle reduction. Materials and Methods: Aerial root was collected and its phytochemical was extracted with acetone and phytochemical detected by GCMS. AgNP is characterized by UV and SEM analysis. DPPPH antioxidant, and AchE inhibition were performed. Results: GCMS reveals 20 different peaks 19 different compounds predominantly with 2-Lauro-1,3-Didecoin, Alpha. Tocospiro A and 2h-1,2,3- Triazole-4-Carboxylic Acid, 2-(2-Fluorophenyl). The extract reduced silver at a 1:9 ratio and the time frame were recorded by 5 min to produce nanoparticles. The UV-vis adsorption spectra show the absorbance peak in the range of 430 nm and SEM reveals size of AgNP was 62 nm rectangle shapes. The free radical scavenging activity of hydroalcoholic extract of F. benghalensis root was determined and found to be more effective antioxidant activity than standard. AchE inhibition was moderate on root extract and significantly inhibited by AgNP. Conclusion: Green silver nanoparticle reduced by aerial root and its antioxidant potential along with inhibition of Acetylcholine esterase is still considered the main therapeutic strategy against Alzheimer’s Disease. The study plant F. benghalensis will improve cognitive function and were screened for acetylcholinesterase inhibitory activity with nano drug delivery also a better candidate for future disease-modifying therapies against this devastating disease.